解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25-hydroxycholesterol (25HC). 25HC is involved in regulating cholesterol biosynt...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01808-16
更新日期:2016-12-20 00:00:00
abstract::Fungi in the genus Pneumocystis live in the lungs of mammals, where they can cause a fatal pneumonia (PCP [Pneumocystis pneumonia]) in hosts with compromised immune systems. The absence of a continuous in vitro culture system for any species of Pneumocystis has led to limited understanding of these fungi, especially f...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01851-16
更新日期:2016-12-13 00:00:00
abstract::The members of the OM43 clade of Betaproteobacteria are abundant coastal methylotrophs with a range of carbon-utilizing capabilities. However, their underlying transcriptional and metabolic responses to shifting conditions or different carbon substrates remain poorly understood. We examined the transcriptional dynamic...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01279-16
更新日期:2016-11-22 00:00:00
abstract::Escherichia coli mazEF is an extensively studied stress-induced toxin-antitoxin (TA) system. The toxin MazF is an endoribonuclease that cleaves RNAs at ACA sites. Thereby, under stress, the induced MazF generates a stress-induced translation machinery (STM), composed of MazF-processed mRNAs and selective ribosomes tha...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01855-16
更新日期:2016-11-15 00:00:00
abstract::Gammaherpesviruses (γHVs) are generally considered host specific and to have codiverged with their hosts over millions of years. This tenet is challenged here by broad-scale phylogenetic analysis of two viral genes using the largest sample of mammalian γHVs to date, integrating for the first time bat γHV sequences ava...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01425-16
更新日期:2016-11-08 00:00:00
abstract::The disease mechanisms associated with the onset of astrovirus diarrhea are unknown. Unlike other enteric virus infections, astrovirus infection is not associated with an inflammatory response or cellular damage. In vitro studies in differentiated Caco-2 cells demonstrated that human astrovirus serotype 1 (HAstV-1) ca...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01494-16
更新日期:2016-11-01 00:00:00
abstract::Bacteria of the phylum Bacteroidetes, including commensal organisms and opportunistic pathogens, harbor abundant surface-exposed multiprotein membrane complexes (Sus-like systems) involved in carbohydrate acquisition. These complexes have been mostly linked to commensalism, and in some instances, they have also been s...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01232-16
更新日期:2016-10-25 00:00:00
abstract::Heme oxygenase-1 (HO-1) is a stress response antioxidant enzyme which catalyzes the degradation of heme released during inflammation. HO-1 expression is upregulated in both experimental and human Mycobacterium tuberculosis infection, and in patients it is a biomarker of active disease. Whether the enzyme plays a prote...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01675-16
更新日期:2016-10-25 00:00:00
abstract::Biofilm-associated polymicrobial infections, particularly those involving fungi and bacteria, are responsible for significant morbidity and mortality and tend to be challenging to treat. Candida albicans and Staphylococcus aureus specifically are considered leading opportunistic fungal and bacterial pathogens, respect...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01365-16
更新日期:2016-10-11 00:00:00
abstract::An operon comprising two genes, CA_P0037 and CA_P0036, that encode proteins of unknown function that were previously shown to be highly expressed in acidogenic cells and repressed in solventogenic and alcohologenic cells is located on the pSOL1 megaplasmid of Clostridium acetobutylicum upstream of adhE2 A CA_P0037::in...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01218-16
更新日期:2016-10-04 00:00:00
abstract::Streptococcus pneumoniae causes a high burden of invasive pneumococcal disease (IPD) globally, especially in children from resource-poor settings. Like many bacteria, the pneumococcus can import DNA from other strains or even species by transformation and homologous recombination, which has allowed the pneumococcus to...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01053-16
更新日期:2016-09-27 00:00:00
abstract:UNLABELLED:The world is at the precipice of a postantibiotic era in which medical procedures and minor injuries can result in bacterial infections that are no longer effectively treated by antibiotics. Cathelicidins are peptides produced by animals to combat bacterial infections and to regulate innate immune responses....
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01418-16
更新日期:2016-09-20 00:00:00
abstract:UNLABELLED:Similar to many eukaryotic viruses (and unlike bacteriophages), viruses infecting archaea are often encased in lipid-containing envelopes. However, the mechanisms of their morphogenesis and egress remain unexplored. Here, we used dual-axis electron tomography (ET) to characterize the morphogenesis of Sulfolo...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01439-16
更新日期:2016-09-13 00:00:00
abstract:UNLABELLED:A mechanistic understanding of the determination and maintenance of the simplest bacterial cell shape, a sphere, remains elusive compared with that of more complex shapes. Cocci seem to lack a dedicated elongation machinery, and a spherical shape has been considered an evolutionary dead-end morphology, as a ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00908-16
更新日期:2016-09-06 00:00:00
abstract::Mycobacterium bovis BCG is the only available vaccine for protection against tuberculosis (TB). While BCG protects children from severe disease, it has little impact on pulmonary disease in adults. A recombinant BCG vaccine BCG ΔureC::hly (strain VPM1002) is in advanced clinical trials and shows promise for improved v...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01370-16
更新日期:2016-08-30 00:00:00
abstract:UNLABELLED:Glycoside hydrolases (GHs) are key enzymes in the depolymerization of plant-derived cellulose, a process central to the global carbon cycle and the conversion of plant biomass to fuels and chemicals. A limited number of GH families hydrolyze crystalline cellulose, often by a processive mechanism along the ce...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01106-16
更新日期:2016-08-23 00:00:00
abstract:UNLABELLED:Significant gut microbiota heterogeneity exists among ulcerative colitis (UC) patients, though the clinical implications of this variance are unknown. We hypothesized that ethnically distinct UC patients exhibit discrete gut microbiotas with unique metabolic programming that differentially influence immune a...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01072-16
更新日期:2016-08-16 00:00:00
abstract:UNLABELLED:The outer membrane (OM) of Gram-negative bacteria provides protection against toxic molecules, including reactive oxygen species (ROS). Decreased OM permeability can promote bacterial survival under harsh circumstances and protects against antibiotics. To better understand the regulation of OM permeability, ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01238-16
更新日期:2016-08-09 00:00:00
abstract:UNLABELLED:Toxoplasma gondii is an obligate intracellular parasite that invades host cells and replicates within a unique parasitophorous vacuole. To maintain this intracellular niche, the parasite secretes an array of dense granule proteins (GRAs) into the nascent parasitophorous vacuole. These GRAs are believed to pl...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00808-16
更新日期:2016-08-02 00:00:00
abstract:UNLABELLED:Members of the genus Vibrio include many pathogens of humans and marine animals that share genetic information via horizontal gene transfer. Hence, the Vibrio pan-genome carries the potential to establish new pathogenic strains by sharing virulence determinants, many of which have yet to be characterized. He...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01077-16
更新日期:2016-07-26 00:00:00
abstract:UNLABELLED:Despite their high genomic diversity, all known viruses are structurally constrained to a limited number of virion morphotypes. One morphotype of viruses infecting bacteria, archaea, and eukaryotes is the tailless icosahedral morphotype with an internal membrane. Although it is considered an abundant morphot...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00699-16
更新日期:2016-07-19 00:00:00
abstract:UNLABELLED:Anti-tumor necrosis factor alpha (anti-TNF-α) therapies have been increasingly used to treat inflammatory diseases and are associated with increased risk of invasive fungal infections, including Cryptococcus neoformans infection. Using a mouse model of cryptococcal infection, we investigated the mechanism by...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00510-16
更新日期:2016-07-12 00:00:00
abstract:UNLABELLED:Mutations in the Plasmodium falciparum cyclic amine resistance locus (PfCARL) are associated with parasite resistance to the imidazolopiperazines, a potent class of novel antimalarial compounds that display both prophylactic and transmission-blocking activity, in addition to activity against blood-stage para...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00696-16
更新日期:2016-07-05 00:00:00
abstract:UNLABELLED:Enteropathogenic Escherichia coli (EPEC) has the ability to antagonize host apoptosis during infection through promotion and inhibition of effectors injected by the type III secretion system (T3SS), but the total number of these effectors and the overall functional relationships between these effectors durin...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00479-16
更新日期:2016-06-21 00:00:00
abstract:UNLABELLED:β-Lactam antibiotics are the drugs of choice to treat pneumococcal infections. The spread of β-lactam-resistant pneumococci is a major concern in choosing an effective therapy for patients. Systematically tracking β-lactam resistance could benefit disease surveillance. Here we developed a classification syst...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00756-16
更新日期:2016-06-14 00:00:00
abstract:UNLABELLED:Curing HIV-1 infection will require elimination of persistent cellular reservoirs that harbor latent virus in the face of combination antiretroviral therapy (cART). Proposed immunotherapeutic strategies to cure HIV-1 infection include enhancing lysis of these infected cells by cytotoxic T lymphocytes (CTL). ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00473-16
更新日期:2016-05-31 00:00:00
abstract:UNLABELLED:The current tuberculosis (TB) vaccine, Mycobacterium bovis Bacillus Calmette-Guérin (BCG), provides insufficient protection against pulmonary TB. Previously, we generated a listeriolysin-expressing recombinant BCG strain, which to date has successfully completed phase I and phase IIa clinical trials. In an a...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00679-16
更新日期:2016-05-24 00:00:00
abstract:UNLABELLED:Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal meningitis in immunocompromised individuals. Treatment options for cryptococcosis are limited. Of the two major antifungal drug classes, azoles are active against C. neoformans but exert a fungistatic effect, necessitating long tr...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00478-16
更新日期:2016-05-10 00:00:00
abstract:UNLABELLED:In the model eukaryote Saccharomyces cerevisiae, the transcription factor Cst6p has been reported to play important roles in several biological processes. However, the genome-wide targets of Cst6p and its physiological functions remain unknown. Here, we mapped the genome-wide binding sites of Cst6p at high r...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00559-16
更新日期:2016-05-03 00:00:00
abstract:UNLABELLED:Conjugate vaccines are known to be one of the most effective and safest types of vaccines against bacterial pathogens. Previously, vaccine biosynthesis has been performed by using N-linked glycosylation systems. However, the structural specificity of these systems for sugar substrates has hindered their appl...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00443-16
更新日期:2016-04-26 00:00:00
abstract:UNLABELLED:Despite long-term investment, influenza continues to be a significant worldwide problem. The cornerstone of protection remains vaccination, and approved vaccines seek to elicit a hemagglutination inhibition (HAI) titer of ≥1:40 as the primary correlate of protection. However, recent poor vaccine performance ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00417-16
更新日期:2016-04-19 00:00:00
abstract:UNLABELLED:Mycoplasma pneumoniae, a pathogenic bacterium, glides on host surfaces using a unique mechanism. It forms an attachment organelle at a cell pole as a protrusion comprised of knoblike surface structures and an internal core. Here, we analyzed the three-dimensional structure of the organelle in detail by elect...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00243-16
更新日期:2016-04-12 00:00:00
abstract:UNLABELLED:The promoter most strongly induced upon activation of the Cpx two-component envelope stress response is the cpxP promoter. The 3' untranscribed region (UTR) of the cpxP transcript is shown to produce a small RNA (sRNA), CpxQ. We investigated the role of CpxQ in combating envelope stress. Remarkably, the two ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00312-16
更新日期:2016-04-05 00:00:00
abstract:UNLABELLED:Middle East respiratory syndrome coronavirus (MERS-CoV) is the first highly pathogenic human coronavirus to emerge since severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. Like many coronaviruses, MERS-CoV carries genes that encode multiple accessory proteins that are not required for replicat...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00258-16
更新日期:2016-03-29 00:00:00
abstract:UNLABELLED:Moraxella catarrhalis is a human respiratory pathogen that causes acute otitis media in children and is associated with exacerbations in patients suffering from chronic obstructive pulmonary disease (COPD). The first step in M. catarrhalis colonization is adherence to the mucosa, epithelial cells, and extrac...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00066-16
更新日期:2016-03-22 00:00:00
abstract:UNLABELLED:Salmonella enterica serovar Typhimurium is one of the most common S. enterica serovars associated with U.S. foodborne outbreaks. S. Typhimurium bacteria isolated from humans exhibit wide-ranging virulence phenotypes in inbred mice, leading to speculation that some strains are more virulent in nature. However...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00154-16
更新日期:2016-03-08 00:00:00
abstract:UNLABELLED:The newly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe respiratory infection with a high mortality rate (~35%). MERS-CoV has been a global threat due to continuous outbreaks in the Arabian peninsula and international spread by infected travelers since 2012. From May to Jul...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00019-16
更新日期:2016-03-01 00:00:00
abstract::Like their cellular hosts, herpesviruses are subject to the regulatory impacts of chromatin assembled on their genomes. Upon infection, these viruses are assembled into domains of chromatin with heterochromatic signatures that suppress viral gene expression or euchromatic characteristics that promote gene expression. ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00098-16
更新日期:2016-02-16 00:00:00
abstract:UNLABELLED:In Staphylococcus aureus, hundreds of small regulatory or small RNAs (sRNAs) have been identified, yet this class of molecule remains poorly understood and severely understudied. sRNA genes are typically absent from genome annotation files, and as a consequence, their existence is often overlooked, particula...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01990-15
更新日期:2016-02-09 00:00:00
abstract:UNLABELLED:Infection by alphaherpesviruses, including herpes simplex virus (HSV) and pseudorabies virus (PRV), typically begins at epithelial surfaces and continues into the peripheral nervous system (PNS). Inflammatory responses are induced at the infected peripheral site prior to invasion of the PNS. When the periphe...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02145-15
更新日期:2016-02-02 00:00:00